Ragdoll & Bengal Kittens
Health Tested ..... Breeder Approved
All of our breeding cats are genetically health tested and are negative of the following. This means your new kitten will be as well.
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Mode of Inheritance: Autosomal dominant (incomplete penetrance). Alleles: N = Normal, HCMmc = hypertrophic cardiomyopathy-associated mutation.
Explanation of Results:
N/N genotype are not predicted to be at increased risk of HCM and cannot transmit this hypertrophic cardiomyopathy-associated mutation to their offspring.
N/HCMmc genotype are 1.8 times more likely to develop HCM than cats without the mutation (N/N genotype). They will transmit this hypertrophic cardiomyopathy-associated mutation to 50% of their offspring.
HCMmc/HCMmc genotype are 18 times more likely to develop HCM than cats without the mutation (N/N genotype). Cats with this genotype are at highest risk for sudden cardiac death.
Having two copies of the disease-associated mutation, moderate to severe cardiac disease can lead to sudden death by age 4 years or less. Cats that carry one copy of the mutation have a longer life expectancy, but may still develop HCM.
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PKD is an inherited condition in cats that causes multiple cysts (pockets of fluid) to form in the kidneys. These cysts are present from birth. Initially they are very small but they grow larger over time and may eventually disrupt kidney function resulting in kidney failure.
PKD is the result of a single, autosomal dominant gene abnormality. This means that every cat with the abnormal gene will have PKD. A cat only needs one of its parents to be affected with PKD in order to inherit the abnormal gene and be affected itself.
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SMA is an autosomal recessive disorder. The disease affects cats with P/P (positive / positive) genotype only. Cats with P/N (positive /negative) genotype are clinically without any symptoms.
It is a neurodegenerative disorder caused by death of spinal cord neurons that activate skeletal muscles of the trunk and limbs. Loss of neurons in the first few months of life leads to muscle weakness and atrophy that first becomes apparent at 3-4 months of age. Affected kittens develop an odd gait with a sway of the hindquarters, are usually too weak to jump and stand with the hocks nearly touching. By 5-6 months of age, severe weakness in the hindquarters is apparent and muscle mass is reduced. Affected cats are not in pain and most live very comfortably as indoor cats for many years.
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PKDef is an autosomal recessive disorder. The disease affects cats with P/P (positive / positive) genotype only. Cats with P/N (positive /negative) genotype are clinically without any symptoms.
Pyruvate kinase (PK) deficiency is the most frequent abnormality of glycolysis, one of the principal pathways of energy (ATP) generation in cells. In erythrocytes, glycolysis is the only pathway for ATP synthesis since mature red cells lack mitochondria. The disease manifests as a chronic, intermittent, hemolytic anemia. Typically, clinical symptoms include but are not limited to: lethargy, diarrhea, pale mucous membranes, lack of appetite, poor coat quality, weight loss, icterus and occasionally splenomegaly. Blood chemistry may reveal anemia, increased aggregated reticulocyte counts, hyperglobulinaemia, hyperbilirubinaemia, and increased liver enzymes. Severity of clinical presentation and age of onset are variable. Clinical signs can first manifest as early as six months and as late as five years.
All of our breeding cats are health tested and are negative of FeLV & FIV. This means your new kitten will be.
Feline leukemia virus (FeLV) is a retrovirus, which develops multiple clinical symptoms from immune system disorder to oncogenous lymphoproliferatice alterations. All retroviruses (incl. FeLV, FIV and HIV) produce an enzyme, reverse transcriptase, which permits them to insert copies of their own DNA into that of cells they have infected. FeLV and FIV are different genetically, and their protein constituents are dissimilar in size and composition.
Feline Immunodeficiency Virus (FIV) is a representative of lentiviruses belonging to the retrovirus family, which affects CD4′ lymphocytes of the immune system of cats and induces slow, but serious immunodeficiency of the organism. FIV-virus, like other retroviruses, inserts its genetic code into the genome of the host cell by help of reverse transcriptase. It has substantial affinity to the cells of immune system. It replicates in macrophages and lymphocytes and that not only in the auxiliary Th (CD4+) lymphocytes, but also in Tc and B-lymphocytes.
We Are A Closed Cattery
Our cattery is physically in our home. A closed cattery means the cats in our cattery are not exposed to any cats outside of the cattery. It is very important to know if a cattery is open or closed. There are many infectious diseases that can be passed between felines and humans to felines as well. The only protection one has is by purchasing a kitten through a closed cattery. Our Bengals & Ragdolls are FeLV and FIV Negative.